Burkholderia cenocepacia J2315, BCAM1004 (bceN)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM1004
NCBI Locus Tag	QU43_RS59400
Name	bceN Synonym: gca
Replicon	chromosome 2
Genomic location	1112176 - 1113222 (- strand)
Comment	Member of the bce-II gene cluster

Cross-References

RefSeq	WP_006491261.1
GI	206562859
Entrez	6928713
GI	206562859
INSDC	CAR54861.1
NCBI Locus Tag	QU43_RS59400
NCBI Old Locus Tag	BCAM1004
RefSeq	WP_006491261.1,GeneID
UniParc	UPI00017B9D23
UniProtKB Acc	B4EFL2
UniProtKB ID	B4EFL2_BURCJ
UniRef100	UniRef100_B4EFL2
UniRef50	UniRef50_Q2T7G0
UniRef90	UniRef90_B4EFL2

Product

Feature Type	CDS
Coding Frame	1
Product Name	GDP-D-mannose 4,6-dehydratase BceN Product Name Confidence: Class 1
Synonyms	GCP-mannose 4,6-dehydratase
Evidence for Translation
Charge (pH 7)	-0.61
Kyte-Doolittle Hydrophobicity Value	-0.341
Molecular Weight (kDa)	38958.9
Isoelectric Point (pI)	6.80

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 607 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG003102 (653 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM1004 Search term: bceN Search term: GDP-D-mannose 4,6-dehydratase BceN

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000370194 GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369] E-value: 9.5e-99 Percent Identity: 53.0

References

Biochemical and functional studies on the Burkholderia cepacia complex bceN gene, encoding a GDP-D-mannose 4,6-dehydratase. Sousa SA, Feliciano JR, Pinheiro PF, Leitão JH PLoS One 2013;8(2):e56902 PubMed ID: 23460819

Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions. Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM Appl Environ Microbiol 2010 Jan;76(2):441-50 PubMed ID: 19948863