Burkholderia cenocepacia J2315, BCAM1003 (bceM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM1003
NCBI Locus TagQU43_RS59395
Name
bceM
Replicon chromosome 2
Genomic location 1111224 - 1112189 (- strand)
CommentMember of the bce-II gene cluster

Cross-References

RefSeq WP_006491265.1
GI 206562858
Entrez 6928712
GI 206562858
INSDC CAR54860.1
NCBI Locus Tag QU43_RS59395
NCBI Old Locus Tag BCAM1003
RefSeq WP_006491265.1,GeneID
UniParc UPI00017B9D22
UniProtKB Acc B4EFL1
UniProtKB ID B4EFL1_BURCJ
UniRef100 UniRef100_A0A095EAV0
UniRef50 UniRef50_Q4K5C5
UniRef90 UniRef90_M4HPK1

Product

Feature Type CDS
Coding Frame 1
Product Name
GDP-6-deoxy-D-lyxo-4-hexulose reductase BceM
Synonyms putative epimerase
Evidence for Translation
Charge (pH 7) 2.14
Kyte-Doolittle Hydrophobicity Value -0.043
Molecular Weight (kDa) 34430.8
Isoelectric Point (pI) 8.19

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4LW8 ISOMERASE 07/26/13 Crystal structure of a putative epimerase from Burkholderia cenocepacia J2315 BURKHOLDERIA CENOCEPACIA 2.1 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 631 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000738 (646 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM1003
Search term: bceM

Human Homologs

References

Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863