Burkholderia cenocepacia J2315, BCAM0869 (fbp)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM0869
NCBI Locus TagQU43_RS58725
Name
fbp
Replicon chromosome 2
Genomic location 959828 - 960169 (- strand)

Cross-References

RefSeq WP_006482165.1
GI 206562725
Entrez 6928612
GI 206562725
INSDC CAR54727.1
NCBI Locus Tag QU43_RS58725
NCBI Old Locus Tag BCAM0869
RefSeq WP_006482165.1,GeneID
UniParc UPI00017B9A32
UniProtKB Acc B4EMY8
UniProtKB ID B4EMY8_BURCJ
UniRef100 UniRef100_B4EMY8
UniRef50 UniRef50_Q2T7U5
UniRef90 UniRef90_Q2T7U5

Product

Feature Type CDS
Coding Frame 1
Product Name
peptidyl-prolyl cis-trans isomerase
Synonyms
Evidence for Translation
Charge (pH 7) -2.77
Kyte-Doolittle Hydrophobicity Value -0.108
Molecular Weight (kDa) 11884.4
Isoelectric Point (pI) 4.75

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3UQA Isomerase, protein binding 11/19/11 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation A54E from Burkholderia pseudomallei complexed with FK506 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.55 X-RAY DIFFRACTION 92.9
2KO7 ISOMERASE 09/11/09 Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with Cycloheximide-N-ethylethanoate BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 93.8
4FN2 Isomerase, protein binding 06/19/12 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ37 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.95 X-RAY DIFFRACTION 92.9
3UF8 Isomerase, protein binding 10/31/11 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with a G95A surface mutation from Burkholderia pseudomallei complexed with FK506 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.5 X-RAY DIFFRACTION 92.9
4GGQ Isomerase, protein binding 08/07/12 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.95 X-RAY DIFFRACTION 93.8
5V8T ISOMERASE 03/22/17 Crystal structure of SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with SF354 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); BURKHOLDERIA PSEUDOMALLEI 2.1 X-RAY DIFFRACTION 93.8
2KE0 ISOMERASE 01/21/09 Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 93.8
4G50 Isomerase, protein binding 07/17/12 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ168 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.75 X-RAY DIFFRACTION 92.9
4GIV Isomerase, protein binding 08/09/12 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 2.45 X-RAY DIFFRACTION 92.9
2Y78 ISOMERASE 01/28/11 Crystal structure of BPSS1823, a Mip-like chaperone from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 0.91 X-RAY DIFFRACTION 93.8
5KLX ISOMERASE, protein binding 06/26/16 Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 2.45 X-RAY DIFFRACTION 93.8
4DZ3 ISOMERASE 02/29/12 Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation M61H from Burkholderia pseudomallei complexed with FK506 BURKHOLDERIA PSEUDOMALLEI 2.0 X-RAY DIFFRACTION 92.9
3VAW Isomerase, PROTEIN BINDING/INHIBITOR 12/29/11 Crystal structure of a smt fusion peptidyl-prolyl cis-trans isomerase with surface mutation v3i from burkholderia pseudomallei complexed with fk506 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); BURKHOLDERIA PSEUDOMALLEI 1.55 X-RAY DIFFRACTION 92.9
2L2S ISOMERASE 08/27/10 Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with 1-{[(4-methylphenyl)thio]acetyl}piperidine BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 93.8

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 431 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004859 (637 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM0869
Search term: fbp

Human Homologs

Ensembl 97, assembly GRCh38.p12
FKBP prolyl isomerase 1A [Source:HGNC Symbol;Acc:HGNC:3711]
E-value: 2.3e-25
Percent Identity: 54.8
Ensembl 97, assembly GRCh38.p12
FKBP prolyl isomerase 1A [Source:HGNC Symbol;Acc:HGNC:3711]
E-value: 2.3e-25
Percent Identity: 54.8

References

No references are associated with this feature.