Burkholderia cenocepacia J2315, BCAM0857 (bceD)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM0857
NCBI Locus Tag	QU43_RS58665
Name	bceD
Replicon	chromosome 2
Genomic location	945391 - 945834 (+ strand)
Comment	Member of the bce-I gene cluster

Cross-References

RefSeq	WP_006482944.1
GI	206562713
Entrez	6930372
GI	206562713
INSDC	CAR54715.1
NCBI Locus Tag	QU43_RS58665
NCBI Old Locus Tag	BCAM0857
RefSeq	WP_006482944.1,GeneID
UniParc	UPI00017B99F0
UniProtKB Acc	B4EMX6
UniProtKB ID	B4EMX6_BURCJ
UniRef100	UniRef100_B4EMX6
UniRef50	UniRef50_Q2T7V4
UniRef90	UniRef90_A0A095E814

Product

Feature Type	CDS
Coding Frame	1
Product Name	phosphotyrosine phosphatase BceD Product Name Confidence: Class 1
Synonyms	phosphotyrosine phosphatase BceD
Evidence for Translation
Charge (pH 7)	4.58
Kyte-Doolittle Hydrophobicity Value	-0.307
Molecular Weight (kDa)	16315.5
Isoelectric Point (pI)	8.92

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 290 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG004849 (632 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM0857 Search term: bceD Search term: phosphotyrosine phosphatase BceD

Human Homologs

References

Functional analysis of Burkholderia cepacia genes bceD and bceF, encoding a phosphotyrosine phosphatase and a tyrosine autokinase, respectively: role in exopolysaccharide biosynthesis and biofilm formation. Ferreira AS, Leitão JH, Sousa SA, Cosme AM, Sá-Correia I, Moreira LM Appl Environ Microbiol 2007 Jan;73(2):524-34 PubMed ID: 17114319

Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions. Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM Appl Environ Microbiol 2010 Jan;76(2):441-50 PubMed ID: 19948863

Tyrosine Phosphorylation and Dephosphorylation in Burkholderia cenocepacia Affect Biofilm Formation, Growth under Nutritional Deprivation, and Pathogenicity. Andrade A, Tavares-Carreón F, Khodai-Kalaki M, Valvano MA Appl Environ Microbiol 2016 Feb 1;82(3):843-56 PubMed ID: 26590274

The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line. Ferreira AS, Silva IN, Fernandes F, Pilkington R, Callaghan M, McClean S, Moreira LM Infect Immun 2015 Feb;83(2):812-21 PubMed ID: 25486990