Burkholderia cenocepacia J2315, BCAM0379 (atsR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM0379
NCBI Locus TagQU43_RS56275
Name
atsR
Replicon chromosome 2
Genomic location 429194 - 431014 (- strand)

Cross-References

RefSeq WP_006485471.1
GI 206562240
Entrez 6928163
GI 206562240
INSDC CAR54235.1
NCBI Locus Tag QU43_RS56275
NCBI Old Locus Tag BCAM0379
RefSeq WP_006485471.1,GeneID
UniParc UPI00017B9BCF
UniProtKB Acc B4EIW7
UniProtKB ID B4EIW7_BURCJ
UniRef100 UniRef100_B4EIW7
UniRef50 UniRef50_A3NRV5
UniRef90 UniRef90_B1K780

Product

Feature Type CDS
Coding Frame 1
Product Name
hybrid two-component system kinase-response regulator protein AtsR
Product Name Confidence: Class 1
Synonyms adherence and T6 secretion system regulator AtsR
Evidence for Translation
Charge (pH 7) -0.89
Kyte-Doolittle Hydrophobicity Value 0.019
Molecular Weight (kDa) 67142.7
Isoelectric Point (pI) 6.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 618 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004546 (629 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM0379
Search term: atsR

Human Homologs

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
The Burkholderia cenocepacia sensor kinase hybrid AtsR is a global regulator modulating quorum-sensing signalling.
Aubert DF, O'Grady EP, Hamad MA, Sokol PA, Valvano MA
Environ Microbiol 2013 Feb;15(2):372-85
PubMed ID: 22830644