Burkholderia cenocepacia J2315, BCAM0325 (virB2)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM0325
NCBI Locus Tag	QU43_RS56035
Name	virB2 Synonym: bcvirB2
Replicon	chromosome 2
Genomic location	380323 - 380676 (+ strand)
Comment	This gene is part of the B. cenocepacia J2315 VirB-VirD-like type IV secretion system cluster.

Cross-References

RefSeq	WP_012493064.1
GI	206562191
Entrez	6928114
GI	206562191
INSDC	CAR54184.1
NCBI Locus Tag	QU43_RS56035
NCBI Old Locus Tag	BCAM0325
RefSeq	WP_012493064.1,GeneID
UniParc	UPI00017B9AF6
UniProtKB Acc	B4EIR6
UniProtKB ID	B4EIR6_BURCJ
UniRef100	UniRef100_A0A095GGK5
UniRef50	UniRef50_Q13XI6
UniRef90	UniRef90_Q1BKX4

Product

Feature Type	CDS
Coding Frame	1
Product Name	putative type IV secretion system protein VirB2 Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7)	6.37
Kyte-Doolittle Hydrophobicity Value	1.069
Molecular Weight (kDa)	12669.3
Isoelectric Point (pI)	10.48

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 11 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG006325 (52 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM0325 Search term: virB2 Search term: putative type IV secretion system protein VirB2

Human Homologs

References

Involvement of a plasmid-encoded type IV secretion system in the plant tissue watersoaking phenotype of Burkholderia cenocepacia. Engledow AS, Medrano EG, Mahenthiralingam E, LiPuma JJ, Gonzalez CF J Bacteriol 2004 Sep;186(18):6015-24 PubMed ID: 15342570

Two type IV secretion systems with different functions in Burkholderia cenocepacia K56-2. Zhang R, LiPuma JJ, Gonzalez CF Microbiology 2009 Dec;155(Pt 12):4005-4013 PubMed ID: 19744991

A type IV secretion system contributes to intracellular survival and replication of Burkholderia cenocepacia. Sajjan SU, Carmody LA, Gonzalez CF, LiPuma JJ Infect Immun 2008 Dec;76(12):5447-55 PubMed ID: 18824538