Burkholderia cenocepacia J2315, BCAM0224

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
NCBI Locus TagQU43_RS55540
Replicon chromosome 2
Genomic location 275952 - 278813 (- strand)
CommentBCAM0224 is a trimeric autotransporter adhesin required for cell adhesion and virulence (PMID:20019083)


RefSeq WP_006489549.1
GI 206562094
Entrez 6928019
GI 206562094
INSDC CAR54082.1
NCBI Locus Tag QU43_RS55540
NCBI Old Locus Tag BCAM0224
RefSeq WP_006489549.1,GeneID
UniParc UPI00017B9DF9
UniProtKB Acc B4EHQ6
UniRef100 UniRef100_A0A0D1DIC1
UniRef50 UniRef50_A0A0B2AXQ5
UniRef90 UniRef90_A0A0D1DIC1


Feature Type CDS
Coding Frame 1
Product Name
collagen type 1-binding trimeric autotransporter adhesin
Product Name Confidence: Class 1
Synonyms collagen-binding trimeric autotransporter adhesin
Evidence for Translation
Charge (pH 7) -30.87
Kyte-Doolittle Hydrophobicity Value 0.094
Molecular Weight (kDa) 90289.5
Isoelectric Point (pI) 4.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 69 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002926 (1913 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BCAM0224

Human Homologs


A BCAM0223 mutant of Burkholderia cenocepacia is deficient in hemagglutination, serum resistance, adhesion to epithelial cells and virulence.
Mil-Homens D, Fialho AM
PLoS One 2012;7(7):e41747
PubMed ID: 22848588
Genome-wide analysis of DNA repeats in Burkholderia cenocepacia J2315 identifies a novel adhesin-like gene unique to epidemic-associated strains of the ET-12 lineage.
Mil-Homens D, Rocha EPC, Fialho AM
Microbiology 2010 Apr;156(Pt 4):1084-1096
PubMed ID: 20019083
Trimeric autotransporter adhesins in members of the Burkholderia cepacia complex: a multifunctional family of proteins implicated in virulence.
Mil-Homens D, Fialho AM
Front Cell Infect Microbiol 2011;1:13
PubMed ID: 22919579