Burkholderia cenocepacia J2315, BCAM0185 (bclC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM0185
NCBI Locus TagQU43_RS55340
Name
bclC
Replicon chromosome 2
Genomic location 215683 - 216501 (- strand)

Cross-References

RefSeq WP_006490828.1
GI 206562055
Entrez 6927981
GI 206562055
INSDC CAR54043.1
NCBI Locus Tag QU43_RS55340
NCBI Old Locus Tag BCAM0185
RefSeq WP_006490828.1,GeneID
UniParc UPI00017B9D2F
UniProtKB Acc B4EH86
UniProtKB ID B4EH86_BURCJ
UniRef100 UniRef100_B4EH86
UniRef50 UniRef50_A0AWZ7
UniRef90 UniRef90_A0AWZ7

Product

Feature Type CDS
Coding Frame 1
Product Name
lectin
Synonyms
Evidence for Translation
Charge (pH 7) -4.32
Kyte-Doolittle Hydrophobicity Value -0.075
Molecular Weight (kDa) 28282.5
Isoelectric Point (pI) 4.99

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2XR4 SUGAR BINDING PROTEIN 09/09/10 C-terminal domain of BC2L-C Lectin from Burkholderia cenocepacia BURKHOLDERIA CENOCEPACIA 1.9 X-RAY DIFFRACTION 100.0
2WQ4 SUGAR BINDING PROTEIN 08/13/09 N-terminal domain of BC2L-C Lectin from Burkholderia cenocepacia BURKHOLDERIA CENOCEPACIA 1.42 X-RAY DIFFRACTION 100.0
6TID SUGAR BINDING PROTEIN 11/22/19 Structure of the N terminal domain of Bc2L-C lectin (1-131) in complex with H-type 1 antigen BURKHOLDERIA CENOCEPACIA (STRAIN ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) 1.614 X-RAY DIFFRACTION 100.0
6TIG SUGAR BINDING PROTEIN 11/22/19 Structure of the N terminal domain of Bc2L-C lectin (1-131) in complex with Globo H (H-type 3) antigen BURKHOLDERIA CENOCEPACIA J2315 1.9 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 6 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG006279 (98 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM0185
Search term: bclC
Search term: lectin

Human Homologs

References

Identification of functions linking quorum sensing with biofilm formation in Burkholderia cenocepacia H111.
Inhülsen S, Aguilar C, Schmid N, Suppiger A, Riedel K, Eberl L
Microbiologyopen 2012 Jun;1(2):225-42
PubMed ID: 22950027