Burkholderia cenocepacia J2315, BCAL3110 (waaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL3110
NCBI Locus TagQU43_RS52280
Name
waaA
Replicon chromosome 1
Genomic location 3398496 - 3399857 (- strand)

Cross-References

RefSeq WP_012492900.1
GI 206561456
Entrez 6934228
GI 206561456
INSDC CAR53434.1
NCBI Locus Tag QU43_RS52280
NCBI Old Locus Tag BCAL3110
RefSeq WP_012492900.1,GeneID
UniParc UPI00017B994E
UniProtKB Acc B4ECD1
UniProtKB ID B4ECD1_BURCJ
UniRef100 UniRef100_A0A0D1DGE6
UniRef50 UniRef50_B3R5Y1
UniRef90 UniRef90_A9AF76

Product

Feature Type CDS
Coding Frame 1
Product Name
WaaA
Product Name Confidence: Class 2
Synonyms 3-deoxy-D-manno-octulosonic-acid transferase
Evidence for Translation
Charge (pH 7) 6.30
Kyte-Doolittle Hydrophobicity Value 0.094
Molecular Weight (kDa) 48662.4
Isoelectric Point (pI) 8.91

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 345 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000752 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL3110
Search term: waaA
Search term: WaaA

References

Reconstitution of O-specific lipopolysaccharide expression in Burkholderia cenocepacia strain J2315, which is associated with transmissible infections in patients with cystic fibrosis.
Ortega X, Hunt TA, Loutet S, Vinion-Dubiel AD, Datta A, Choudhury B, Goldberg JB, Carlson R, Valvano MA
J Bacteriol 2005 Feb;187(4):1324-33
PubMed ID: 15687196
Biosynthesis and structure of the Burkholderia cenocepacia K56-2 lipopolysaccharide core oligosaccharide: truncation of the core oligosaccharide leads to increased binding and sensitivity to polymyxin B.
Ortega X, Silipo A, Saldías MS, Bates CC, Molinaro A, Valvano MA
J Biol Chem 2009 Aug 7;284(32):21738-51
PubMed ID: 19525227
The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in Burkholderia cenocepacia.
Fathy Mohamed Y, Hamad M, Ortega XP, Valvano MA
Mol Microbiol 2017 Apr;104(1):144-162
PubMed ID: 28085228