Burkholderia cenocepacia J2315, BCAL2942 (cysM)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL2942
NCBI Locus Tag	QU43_RS51355
Name	cysM
Replicon	chromosome 1
Genomic location	3220657 - 3221559 (- strand)

Cross-References

RefSeq	WP_012492863.1
GI	206561277
Entrez	6932890
GI	206561277
INSDC	CAR53243.1
NCBI Locus Tag	QU43_RS51355
NCBI Old Locus Tag	BCAL2942
RefSeq	WP_012492863.1,GeneID
UniParc	UPI00017B972F
UniProtKB Acc	B4EB32
UniProtKB ID	B4EB32_BURCJ
UniRef100	UniRef100_B4EB32
UniRef50	UniRef50_P16703
UniRef90	UniRef90_B4EB32

Product

Feature Type	CDS
Coding Frame	1
Product Name	cysteine synthase B Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7)	-2.57
Kyte-Doolittle Hydrophobicity Value	-0.175
Molecular Weight (kDa)	32449.8
Isoelectric Point (pI)	5.52

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 625 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000897 (654 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL2942 Search term: cysM Search term: cysteine synthase B

Human Homologs

Ensembl 97, assembly GRCh38.p12	ENSP00000479559 cystathionine-beta-synthase like [Source:HGNC Symbol;Acc:HGNC:51829] E-value: 1.2e-44 Percent Identity: 37.6
Ensembl 97, assembly GRCh38.p12	ENSP00000481719 cystathionine-beta-synthase like [Source:HGNC Symbol;Acc:HGNC:51829] E-value: 1.2e-44 Percent Identity: 37.6
Ensembl 97, assembly GRCh38.p12	ENSP00000344460 cystathionine-beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550] E-value: 1.2e-44 Percent Identity: 37.6
Ensembl 97, assembly GRCh38.p12	ENSP00000485669 cystathionine-beta-synthase like [Source:HGNC Symbol;Acc:HGNC:51829] E-value: 1.2e-44 Percent Identity: 37.6
Ensembl 97, assembly GRCh38.p12	ENSP00000485527 cystathionine-beta-synthase like [Source:HGNC Symbol;Acc:HGNC:51829] E-value: 1.2e-44 Percent Identity: 37.6
Ensembl 97, assembly GRCh38.p12	ENSP00000381234 cystathionine-beta-synthase like [Source:HGNC Symbol;Acc:HGNC:51829] E-value: 1.2e-44 Percent Identity: 37.6
Ensembl 97, assembly GRCh38.p12	ENSP00000381231 cystathionine-beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550] E-value: 1.2e-44 Percent Identity: 37.6
Ensembl 97, assembly GRCh38.p12	ENSP00000352643 cystathionine-beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550] E-value: 1.2e-44 Percent Identity: 37.6
Ensembl 97, assembly GRCh38.p12	ENSP00000381225 cystathionine-beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550] E-value: 1.2e-44 Percent Identity: 37.6

References

A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo. Loutet SA, Flannagan RS, Kooi C, Sokol PA, Valvano MA J Bacteriol 2006 Mar;188(6):2073-80 PubMed ID: 16513737