Burkholderia cenocepacia J2315, BCAL2822 (bpeA)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL2822
NCBI Locus Tag	QU43_RS50725
Name	bpeA
Replicon	chromosome 1
Genomic location	3100527 - 3101801 (- strand)
Comment	Major RND-4 substrates are aztreonam, chloramphenicol, fluoroquinolones, tobramycin
Comment	Member of rnd-4 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-4

Cross-References

RefSeq	WP_006497328.1
GI	206561159
Entrez	6932821
GI	206561159
INSDC	CAR53122.1
NCBI Locus Tag	QU43_RS50725
NCBI Old Locus Tag	BCAL2822
RefSeq	WP_006497328.1,GeneID
UniParc	UPI00017B9981
UniProtKB Acc	B4EA06
UniProtKB ID	B4EA06_BURCJ
UniRef100	UniRef100_B4EA06
UniRef50	UniRef50_Q1CL40
UniRef90	UniRef90_B4EA06

Product

Feature Type	CDS
Coding Frame	1
Product Name	RND-4 efflux system membrane fusion protein Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7)	7.45
Kyte-Doolittle Hydrophobicity Value	0.042
Molecular Weight (kDa)	43445.1
Isoelectric Point (pI)	9.83

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 369 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG002468 (670 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL2822 Search term: bpeA Search term: RND-4 efflux system membrane fusion protein

Human Homologs

References

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance. Buroni S, Pasca MR, Flannagan RS, Bazzini S, Milano A, Bertani I, Venturi V, Valvano MA, Riccardi G BMC Microbiol 2009 Sep 17;9:200 PubMed ID: 19761586

Efflux pump-mediated drug resistance in Burkholderia. Podnecky NL, Rhodes KA, Schweizer HP Front Microbiol 2015;6:305 PubMed ID: 25926825