Burkholderia cenocepacia J2315, BCAL2759 (lpxK)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL2759
NCBI Locus Tag	QU43_RS50410
Name	lpxK
Replicon	chromosome 1
Genomic location	3030950 - 3031978 (+ strand)

Cross-References

RefSeq	WP_006496470.1
GI	206561096
Entrez	6934269
GI	206561096
INSDC	CAR53059.1
NCBI Locus Tag	QU43_RS50410
NCBI Old Locus Tag	BCAL2759
RefSeq	WP_006496470.1,GeneID
UniParc	UPI00017B98A4
UniProtKB Acc	B4E9F8
UniProtKB ID	LPXK_BURCJ
UniRef100	UniRef100_B4E9F8
UniRef50	UniRef50_Q1LR05
UniRef90	UniRef90_B4E9F8

Product

Feature Type	CDS
Coding Frame	1
Product Name	LpxK Product Name Confidence: Class 2
Synonyms	tetraacyldisaccharide 4'-kinase
Evidence for Translation
Charge (pH 7)	7.35
Kyte-Doolittle Hydrophobicity Value	0.107
Molecular Weight (kDa)	36251.2
Isoelectric Point (pI)	9.71

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 347 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG002408 (651 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL2759 Search term: lpxK Search term: LpxK

Human Homologs

References

The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in Burkholderia cenocepacia. Fathy Mohamed Y, Hamad M, Ortega XP, Valvano MA Mol Microbiol 2017 Apr;104(1):144-162 PubMed ID: 28085228