Burkholderia cenocepacia J2315, BCAL2408 (msbA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL2408
NCBI Locus TagQU43_RS48710
Name
msbA
Replicon chromosome 1
Genomic location 2664167 - 2665954 (- strand)

Cross-References

RefSeq WP_012492746.1
GI 206560767
Entrez 6932480
GI 206560767
INSDC CAR52709.1
NCBI Locus Tag QU43_RS48710
NCBI Old Locus Tag BCAL2408
RefSeq WP_012492746.1,GeneID
UniParc UPI00017B985E
UniProtKB Acc B4E6D4
UniProtKB ID B4E6D4_BURCJ
UniRef100 UniRef100_B4E6D4
UniRef50 UniRef50_Q62IG3
UniRef90 UniRef90_B4E6D4

Product

Feature Type CDS
Coding Frame 1
Product Name
lipid A export ATP-binding/permease MsbA
Product Name Confidence: Class 2
Synonyms MsbA
Evidence for Translation
Charge (pH 7) 7.39
Kyte-Doolittle Hydrophobicity Value 0.254
Molecular Weight (kDa) 64915.0
Isoelectric Point (pI) 9.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002193 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL2408
Search term: msbA

Human Homologs

Ensembl 97, assembly GRCh38.p12
ATP binding cassette subfamily B member 6 (Langereis blood group) [Source:HGNC Symbol;Acc:HGNC:47]
E-value: 5.1e-68
Percent Identity: 40.1

Human Homologs

Ensembl 97, assembly GRCh38.p12
ATP binding cassette subfamily B member 6 (Langereis blood group) [Source:HGNC Symbol;Acc:HGNC:47]
E-value: 5.1e-68
Percent Identity: 40.1

References

Biosynthesis and structure of the Burkholderia cenocepacia K56-2 lipopolysaccharide core oligosaccharide: truncation of the core oligosaccharide leads to increased binding and sensitivity to polymyxin B.
Ortega X, Silipo A, Saldías MS, Bates CC, Molinaro A, Valvano MA
J Biol Chem 2009 Aug 7;284(32):21738-51
PubMed ID: 19525227
The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in Burkholderia cenocepacia.
Fathy Mohamed Y, Hamad M, Ortega XP, Valvano MA
Mol Microbiol 2017 Apr;104(1):144-162
PubMed ID: 28085228
Mutational analysis and properties of the msbA gene of Escherichia coli, coding for an essential ABC family transporter.
Polissi A, Georgopoulos C
Mol Microbiol 1996 Jun;20(6):1221-33
PubMed ID: 8809774