Burkholderia cenocepacia J2315, BCAL2154 (lpxH)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL2154
NCBI Locus Tag	QU43_RS47385
Name	lpxH
Replicon	chromosome 1
Genomic location	2379096 - 2379896 (+ strand)

Cross-References

RefSeq	WP_006483982.1
GI	206560517
Entrez	6933982
GI	206560517
INSDC	CAR52456.1
NCBI Locus Tag	QU43_RS47385
NCBI Old Locus Tag	BCAL2154
RefSeq	WP_006483982.1,GeneID
UniParc	UPI00017B952E
UniProtKB Acc	B4ED77
UniProtKB ID	B4ED77_BURCJ
UniRef100	UniRef100_B4ED77
UniRef50	UniRef50_A1V5H2
UniRef90	UniRef90_B4ED77

Product

Feature Type	CDS
Coding Frame	1
Product Name	UDP-2,3-diacylglucosamine hydrolase Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7)	5.61
Kyte-Doolittle Hydrophobicity Value	-0.171
Molecular Weight (kDa)	29983.0
Isoelectric Point (pI)	9.37

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 201 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG001974 (654 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL2154 Search term: lpxH Search term: UDP-2,3-diacylglucosamine hydrolase

Human Homologs

References

The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in Burkholderia cenocepacia. Fathy Mohamed Y, Hamad M, Ortega XP, Valvano MA Mol Microbiol 2017 Apr;104(1):144-162 PubMed ID: 28085228