Burkholderia cenocepacia J2315, BCAL0998 (rpoE2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0998
NCBI Locus TagQU43_RS41555
Name
rpoE2
Synonym: ecfA1
Replicon chromosome 1
Genomic location 1085335 - 1085934 (+ strand)

Cross-References

RefSeq WP_006490873.1
GI 206559391
Entrez 6931376
GI 206559391
NCBI Locus Tag QU43_RS41555
NCBI Old Locus Tag BCAL0998
RefSeq WP_006490873.1,GeneID
UniProtKB Acc B4EAI0
UniProtKB ID B4EAI0_BURCJ

Product

Feature Type CDS
Coding Frame 1
Product Name
RNA polymerase sigma factor RpoE
Product Name Confidence: Class 1
Synonyms EcfA1
Evidence for Translation
Charge (pH 7) -2.79
Kyte-Doolittle Hydrophobicity Value -0.372
Molecular Weight (kDa) 22593.5
Isoelectric Point (pI) 5.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Alternative Sigma factors
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes rpoE mutant cannot delay phagolysosomal fusion in mouse RAW 264.7 macrophages
Reference 18227267

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 496 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000968 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0998
Search term: rpoE2

References

Architecture of Burkholderia cepacia complex sigma70 gene family: evidence of alternative primary and clade-specific factors, and genomic instability.
Menard A, de Los Santos PE, Graindorge A, Cournoyer B.
BMC Genomics. 2007 Sep 4;8:308.
PubMed ID: 17784948
Burkholderia cenocepacia requires RpoE for growth under stress conditions and delay of phagolysosomal fusion in macrophages.
Flannagan RS, Valvano MA.
Microbiology. 2008 Feb;154(Pt 2):643-53.
PubMed ID: 18227267