Burkholderia cenocepacia J2315, BCAL0350 (tagF)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL0350
NCBI Locus Tag	QU43_RS38285
Name	tagF Synonym: bcsC
Replicon	chromosome 1
Genomic location	377950 - 378939 (- strand)
Comment	Part of the T6SS gene cluster

Cross-References

RefSeq	WP_006483243.1
GI	206558756
Entrez	6930894
GI	206558756
INSDC	CAR50660.1
NCBI Locus Tag	QU43_RS38285
NCBI Old Locus Tag	BCAL0350
RefSeq	WP_006483243.1,GeneID
UniParc	UPI00017B912E
UniProtKB Acc	B4E6S2
UniProtKB ID	B4E6S2_BURCJ
UniRef100	UniRef100_B4E6S2
UniRef50	UniRef50_D8N088
UniRef90	UniRef90_B4E6S2

Product

Feature Type	CDS
Coding Frame	1
Product Name	type VI secretion system-associated protein TagF Product Name Confidence: Class 2
Synonyms	hypothetical protein
Evidence for Translation
Charge (pH 7)	-6.11
Kyte-Doolittle Hydrophobicity Value	0.056
Molecular Weight (kDa)	36149.1
Isoelectric Point (pI)	6.08

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 16 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000377 (643 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL0350 Search term: tagF Search term: type VI secretion system-associated protein TagF

Human Homologs

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia. Aubert DF, Flannagan RS, Valvano MA Infect Immun 2008 May;76(5):1979-91 PubMed ID: 18316384

Structural biology of type VI secretion systems. Cascales E, Cambillau C Philos Trans R Soc Lond B Biol Sci 2012 Apr 19;367(1592):1102-11 PubMed ID: 22411981

Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia. Aubert DF, Hu S, Valvano MA Microbiology 2015 Nov;161(11):2161-73 PubMed ID: 26364149