Burkholderia cenocepacia J2315, BCAL0349 (tagL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0349
NCBI Locus TagQU43_RS38280
Name
tagL
Synonym: bcsD
Replicon chromosome 1
Genomic location 376995 - 377945 (- strand)
CommentPart of the T6SS gene cluster

Cross-References

RefSeq WP_006494417.1
GI 206558755
Entrez 6930893
GI 206558755
INSDC CAR50659.1
NCBI Locus Tag QU43_RS38280
NCBI Old Locus Tag BCAL0349
RefSeq WP_006494417.1,GeneID
UniParc UPI00017B912D
UniProtKB Acc B4E6S1
UniProtKB ID B4E6S1_BURCJ
UniRef100 UniRef100_A0A095DTB9
UniRef50 UniRef50_K0DZU8
UniRef90 UniRef90_A4JB28

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system-associated protein TagL
Product Name Confidence: Class 2
Synonyms putative outer membrane protein
Evidence for Translation
Charge (pH 7) 7.95
Kyte-Doolittle Hydrophobicity Value -0.254
Molecular Weight (kDa) 32760.8
Isoelectric Point (pI) 10.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 445 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000376 (645 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0349
Search term: tagL

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
Anchoring the type VI secretion system to the peptidoglycan: TssL, TagL, TagP... what else?
Aschtgen MS, Thomas MS, Cascales E
Virulence 2010 Nov-Dec;1(6):535-40
PubMed ID: 21178498
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149