Burkholderia cenocepacia J2315, BCAL0347 (tssH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0347
NCBI Locus TagQU43_RS38270
Name
tssH
Synonym: clpV
Synonym: clpB
Replicon chromosome 1
Genomic location 373066 - 375735 (+ strand)
CommentPart of the T6SS gene cluster

Cross-References

RefSeq WP_006484392.1
GI 206558753
Entrez 6930892
GI 206558753
INSDC CAR50657.1
NCBI Locus Tag QU43_RS38270
NCBI Old Locus Tag BCAL0347
RefSeq WP_006484392.1,GeneID
UniParc UPI00017B9102
UniProtKB Acc B4E6R9
UniProtKB ID B4E6R9_BURCJ
UniRef100 UniRef100_A0A0D1BGE8
UniRef50 UniRef50_J7JAP2
UniRef90 UniRef90_J7JAP2

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssH
Product Name Confidence: Class 1
Synonyms putative type VI secretion system protein TssH
Evidence for Translation
Charge (pH 7) -25.53
Kyte-Doolittle Hydrophobicity Value -0.164
Molecular Weight (kDa) 96703.1
Isoelectric Point (pI) 5.16

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 597 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000372 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0347
Search term: tssH

Human Homologs

Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 2.3e-40
Percent Identity: 33.8

Human Homologs

Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 2.3e-40
Percent Identity: 33.8

Human Homologs

Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 2.3e-40
Percent Identity: 33.8

Human Homologs

Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 2.3e-40
Percent Identity: 33.8

Human Homologs

Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 2.3e-40
Percent Identity: 33.8

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion.
Bönemann G, Pietrosiuk A, Diemand A, Zentgraf H, Mogk A
EMBO J 2009 Feb 18;28(4):315-25
PubMed ID: 19131969
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149