Burkholderia cenocepacia J2315, BCAL0346 (tssG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0346
NCBI Locus TagQU43_RS38265
Name
tssG
Synonym: bcsG
Replicon chromosome 1
Genomic location 371924 - 373024 (+ strand)
CommentPart of the T6SS gene cluster

Cross-References

RefSeq WP_006484394.1
GI 206558752
Entrez 6930891
GI 206558752
INSDC CAR50656.1
NCBI Locus Tag QU43_RS38265
NCBI Old Locus Tag BCAL0346
RefSeq WP_006484394.1,GeneID
UniParc UPI00017B9101
UniProtKB Acc B4E6R8
UniProtKB ID B4E6R8_BURCJ
UniRef100 UniRef100_A0A0D1DEJ9
UniRef50 UniRef50_A0A0B6RV29
UniRef90 UniRef90_A4JB24

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssG
Product Name Confidence: Class 1
Synonyms putative type VI secretion system protein TssG
Evidence for Translation
Charge (pH 7) -5.09
Kyte-Doolittle Hydrophobicity Value -0.093
Molecular Weight (kDa) 40293.3
Isoelectric Point (pI) 5.90

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 102 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000371 (648 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0346
Search term: tssG

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the type VI secretion system.
Zoued A, Durand E, Bebeacua C, Brunet YR, Douzi B, Cambillau C, Cascales E, Journet L
J Biol Chem 2013 Sep 20;288(38):27031-41
PubMed ID: 23921384
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149