Burkholderia cenocepacia J2315, BCAL0341 (tssB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0341
NCBI Locus TagQU43_RS38240
Name
tssB
Synonym: bcsL
Replicon chromosome 1
Genomic location 366905 - 367420 (+ strand)
CommentPart of the T6SS gene cluster

Cross-References

RefSeq WP_006484395.1
GI 206558747
Entrez 6930886
GI 206558747
INSDC CAR50651.1
NCBI Locus Tag QU43_RS38240
NCBI Old Locus Tag BCAL0341
RefSeq WP_006484395.1,GeneID
UniParc UPI000052E09E
UniProtKB Acc B4E6R3
UniProtKB ID B4E6R3_BURCJ
UniRef100 UniRef100_A0A071MFD7
UniRef50 UniRef50_B5E876
UniRef90 UniRef90_A0A071MFD7

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssB
Product Name Confidence: Class 1
Synonyms putative type VI secretion system protein TssB
Evidence for Translation
Charge (pH 7) -3.99
Kyte-Doolittle Hydrophobicity Value -0.646
Molecular Weight (kDa) 19245.7
Isoelectric Point (pI) 4.88

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 110 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000366 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0341
Search term: tssB

Human Homologs

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
BcsKC is an essential protein for the type VI secretion system activity in Burkholderia cenocepacia that forms an outer membrane complex with BcsLB.
Aubert D, MacDonald DK, Valvano MA
J Biol Chem 2010 Nov 12;285(46):35988-98
PubMed ID: 20729192
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149