Burkholderia pseudomallei 668, BURPS668_A2183 (orgA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 668
GCF_000015905.1|latest
Locus Tag
BURPS668_A2183
NCBI Locus TagBURPS668_RS25995
Name
orgA
Replicon chromosome II
Genomic location 2118263 - 2118865 (+ strand)

Cross-References

RefSeq YP_001063177.1
GI 126442985
Entrez 4887475
GI 126442985
INSDC ABN85981.1
NCBI Locus Tag BURPS668_RS25995
NCBI Old Locus Tag BURPS668_A2183
RefSeq YP_001063177.1
UniParc UPI00005598B0
UniProtKB Acc A3NLF6
UniProtKB ID A3NLF6_BURP6
UniRef100 UniRef100_A3NLF6
UniRef50 UniRef50_A3MCE7
UniRef90 UniRef90_A3MCE7

Product

Feature Type CDS
Coding Frame 1
Product Name
Oxygen-regulated invasion protein OrgA
Product Name Confidence: Class 2
Synonyms type III secretion apparatus protein OrgA/MxiK
Evidence for Translation
Charge (pH 7) 5.03
Kyte-Doolittle Hydrophobicity Value 0.099
Molecular Weight (kDa) 21574.6
Isoelectric Point (pI) 8.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 9 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019862 (315 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS668_A2183
Search term: orgA

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592