Burkholderia pseudomallei 668, BURPS668_A2159 (bipD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 668
GCF_000015905.1|latest
Locus Tag
BURPS668_A2159
NCBI Locus TagBURPS668_RS25885
Name
bipD
Synonym: ipaD
Replicon chromosome II
Genomic location 2096522 - 2097454 (- strand)

Cross-References

RefSeq WP_004188590.1
GI 126442887
Entrez 4888033
GI 126442887
INSDC ABN85883.1
NCBI Locus Tag BURPS668_RS25885
NCBI Old Locus Tag BURPS668_A2159
RefSeq WP_004188590.1
UniParc UPI000043BD1B
UniProtKB Acc A3NLD2
UniProtKB ID BIPD_BURP6
UniRef100 UniRef100_A3MCH1
UniRef50 UniRef50_Q2T708
UniRef90 UniRef90_A3MCH1

Product

Feature Type CDS
Coding Frame 1
Product Name
type III effector protein IpaD/SipD/SspD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -7.03
Kyte-Doolittle Hydrophobicity Value -0.362
Molecular Weight (kDa) 33975.1
Isoelectric Point (pI) 4.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2IXR TOXIN 07/10/06 BipD of Burkholderia Pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.6 X-RAY DIFFRACTION 99.7
2J9T TOXIN 11/16/06 BipD of Burkholderia Pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.7 X-RAY DIFFRACTION 99.7
2IZP TOXIN 07/25/06 BipD - an invasion protein associated with the type-III secretion system of Burkholderia pseudomallei. BURKHOLDERIA PSEUDOMALLEI 2.1 X-RAY DIFFRACTION 99.7
3NFT TRANSPORT PROTEIN 06/10/10 Near-atomic resolution analysis of BipD- A component of the type-III secretion system of Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 1.51 X-RAY DIFFRACTION 99.7

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 10 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019830 (320 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS668_A2159
Search term: bipD

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
The type III secretion system needle tip complex mediates host cell sensing and translocon insertion.
Veenendaal AK, Hodgkinson JL, Schwarzer L, Stabat D, Zenk SF, Blocker AJ
Mol Microbiol 2007 Mar;63(6):1719-30
PubMed ID: 17367391