Burkholderia pseudomallei 668, BURPS668_A2153 (bopA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 668
GCF_000015905.1|latest
Locus Tag
BURPS668_A2153
NCBI Locus TagBURPS668_RS25855
Name
bopA
Replicon chromosome II
Genomic location 2089499 - 2091037 (- strand)

Cross-References

RefSeq WP_011853452.1
GI 126445249
Entrez 4887799
GI 126445249
INSDC ABN88245.1
NCBI Locus Tag BURPS668_RS25855
NCBI Old Locus Tag BURPS668_A2153
RefSeq WP_011853452.1
UniParc UPI0000F28A9E
UniProtKB Acc A3NLC6
UniProtKB ID BOPA_BURP6
UniRef100 UniRef100_A3NLC6
UniRef50 UniRef50_A3MCH8
UniRef90 UniRef90_A3MCH8

Product

Feature Type CDS
Coding Frame 1
Product Name
BopA protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 23.68
Kyte-Doolittle Hydrophobicity Value -0.523
Molecular Weight (kDa) 56780.5
Isoelectric Point (pI) 10.34

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Host Associated
Note: This is based on PSORTb V3.0 secondary localization prediction
 Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080
Source 2
Database Victors : 1965
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Mus musculus
Notes BopA mutant is attenuated in mice
Reference 19121696

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 3 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019823 (317 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS668_A2153
Search term: bopA
Search term: BopA protein

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592