Burkholderia pseudomallei 1710b, BURPS1710b_3366 (katG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 1710b
GCF_000012785.1|latest
Locus Tag
BURPS1710b_3366
NCBI Locus TagBURPS1710B_RS16455
Name
katG
Replicon chromosome I
Genomic location 3684266 - 3686452 (- strand)

Cross-References

RefSeq WP_004522123.1
GI 76811912
Entrez 3688444
GI 76811912
INSDC ABA50840.1
NCBI Locus Tag BURPS1710B_RS16455
NCBI Old Locus Tag BURPS1710b_3366
RefSeq WP_004522123.1
UniParc UPI0000559F69
UniProtKB Acc Q3JNW6
UniProtKB ID KATG_BURP1
UniRef100 UniRef100_Q3JNW6
UniRef50 UniRef50_P73911
UniRef90 UniRef90_Q2SZ20

Product

Feature Type CDS
Coding Frame 1
Product Name
catalase/peroxidase HPI
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -11.93
Kyte-Doolittle Hydrophobicity Value -0.346
Molecular Weight (kDa) 79445.5
Isoelectric Point (pI) 5.75

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6MPY OXIDOREDUCTASE 10/09/18 B. pseudomallei KatG crystallized in the presence of benzoyl hydrazide BURKHOLDERIA PSEUDOMALLEI 2.0 X-RAY DIFFRACTION 100.0
6MQ0 OXIDOREDUCTASE 10/09/18 B. pseudomallei KatG crystallized in the presence of furoyl hydrazide BURKHOLDERIA PSEUDOMALLEI 1.9 X-RAY DIFFRACTION 100.0
5SW6 OXIDOREDUCTASE 08/08/16 Crystal structure of an oxoferryl species of catalase-peroxidase KatG at pH5.6 BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 1.9 X-RAY DIFFRACTION 100.0
5SX1 OXIDOREDUCTASE 08/09/16 Crystal structure of D141E variant of B. pseudomallei KatG BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 1.8 X-RAY DIFFRACTION 99.9
5KSN OXIDOREDUCTASE 07/08/16 Crystal structure of the S324G variant of catalase-peroxidase from B. pseudomallei with INH bound BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 1.87 X-RAY DIFFRACTION 99.9
6MQ1 OXIDOREDUCTASE 10/09/18 B. pseudomallei KatG crystalized in the presence of ABTS BURKHOLDERIA PSEUDOMALLEI 2.5 X-RAY DIFFRACTION 100.0
5L05 OXIDOREDUCTASE 07/26/16 Crystal structure of catalase-peroxidase KATG of burkholderia pseudomallei treated with INH BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 1.7 X-RAY DIFFRACTION 100.0
5SXT OXIDOREDUCTASE 08/10/16 Crystal structure of the S324T variant of Burkholderia pseudomallei KatG with isonicotinic acid hydrazide bound BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 1.9 X-RAY DIFFRACTION 99.9
5SXS OXIDOREDUCTASE 08/10/16 Crystal structure of catalase-peroxidase KatG with isonicotinic acid hydrazide and AMP bound BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 1.887 X-RAY DIFFRACTION 100.0
5SX3 OXIDOREDUCTASE 08/09/16 Crystal structure of the catalase-peroxidase KatG of B. pseudomaallei at pH 4.5 BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 2.0 X-RAY DIFFRACTION 100.0
5SXQ OXIDOREDUCTASE 08/10/16 Crystal structure of B. pseudomallei KatG with isonicotinic acid hydrazide bound BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 2.1 X-RAY DIFFRACTION 100.0
5SX0 OXIDOREDUCTASE 08/09/16 Crystal structure of an oxoferryl species of catalase-peroxidase KatG at pH7.5 BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 2.0 X-RAY DIFFRACTION 100.0
5SYL OXIDOREDUCTASE 08/11/16 B. pseudomallei KatG with KCN bound BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 1.95 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
2-AMINO-3-(1-HYDROPEROXY-1H-INDOL-3-YL)PROPAN-1-OL DB08638 DrugBank 5.1.5 Q939D2 Catalase-peroxidase 100.0 728 0.0e+00

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 294 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000599 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS1710b_3366
Search term: katG

Human Homologs

References

Characterization of the catalase-peroxidase KatG from Burkholderia pseudomallei by mass spectrometry.
Donald LJ, Krokhin OV, Duckworth HW, Wiseman B, Deemagarn T, Singh R, Switala J, Carpena X, Fita I, Loewen PC
J Biol Chem 2003 Sep 12;278(37):35687-92
PubMed ID: 12832453