Burkholderia pseudomallei 1106a, BURPS1106A_A2067 (bopE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 1106a
GCF_000015925.1|latest
Locus Tag
BURPS1106A_A2067
NCBI Locus TagBURPS1106A_RS25740
Name
bopE
Replicon chromosome II
Genomic location 2030244 - 2031029 (+ strand)

Cross-References

RefSeq WP_004188462.1
GI 126457906
Entrez 4904757
GI 126457906
INSDC ABN95087.1
NCBI Locus Tag BURPS1106A_RS25740
NCBI Old Locus Tag BURPS1106A_A2067
RefSeq WP_004188462.1
UniParc UPI0000441477
UniProtKB Acc A3P6Z0
UniProtKB ID BOPE_BURP0
UniRef100 UniRef100_A3MCH6
UniRef50 UniRef50_Q2T704
UniRef90 UniRef90_Q2T704

Product

Feature Type CDS
Coding Frame 1
Product Name
putative guanine nucleotide exchange factor sopE
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 8.14
Kyte-Doolittle Hydrophobicity Value -0.553
Molecular Weight (kDa) 28735.0
Isoelectric Point (pI) 9.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2JOK CELL INVASION, SIGNALING PROTEIN 03/14/07 NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 99.5
2JOL CELL INVASION, SIGNALING PROTEIN 03/14/07 Average NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 99.5

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 3 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019825 (316 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS1106A_A2067
Search term: bopE

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592