Burkholderia multivorans ATCC 17616, Bmul_5122 (rpfR)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1
Locus Tag
NCBI Locus TagBMUL_RS25815
Replicon chromosome 2
Genomic location 2260844 - 2262847 (- strand)


RefSeq WP_012217627.1
GI 161521657
Entrez 5769908
GI 161521657
NCBI Locus Tag BMUL_RS25815
NCBI Old Locus Tag Bmul_5122
RefSeq WP_012217627.1
UniProtKB Acc A9AQ19


Feature Type CDS
Coding Frame 1
Product Name
cis-2-dodecenoic acid receptor RpfR
Product Name Confidence: Class 2
Synonyms RNase II stability modulator
Evidence for Translation
Charge (pH 7) -10.33
Kyte-Doolittle Hydrophobicity Value -0.045
Molecular Weight (kDa) 73310.6
Isoelectric Point (pI) 6.09

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 458 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004646 (511 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: Bmul_5122
Search term: rpfR


Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH
Proc Natl Acad Sci U S A 2012 Sep 18;109(38):15479-84
PubMed ID: 22949660
Mutation of the cyclic di-GMP phosphodiesterase gene in Burkholderia lata SK875 attenuates virulence and enhances biofilm formation.
Jung HI, Kim YJ, Lee YJ, Lee HS, Lee JK, Kim SK
J Microbiol 2017 Oct;55(10):800-808
PubMed ID: 28956352
High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.
Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, Tolker-Nielsen T, Jenal U, Eberl L
Microbiology 2017 May;163(5):754-764
PubMed ID: 28463102
Cis-2-dodecenoic acid quorum sensing system modulates N-acyl homoserine lactone production through RpfR and cyclic di-GMP turnover in Burkholderia cenocepacia.
Deng Y, Lim A, Wang J, Zhou T, Chen S, Lee J, Dong YH, Zhang LH
BMC Microbiol 2013 Jul 1;13:148
PubMed ID: 23815566