Burkholderia multivorans ATCC 17616, Bmul_4920 (bceA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1
GCF_000018505.1|latest
Locus Tag
Bmul_4920
NCBI Locus TagBMUL_RS24820
Name
bceA
Replicon chromosome 2
Genomic location 2045180 - 2046706 (+ strand)
CommentMember of the bce-I gene cluster

Cross-References

RefSeq WP_012217474.1
GI 161521456
Entrez 5769673
GI 161521456
NCBI Locus Tag BMUL_RS24820
NCBI Old Locus Tag Bmul_4920
RefSeq WP_012217474.1
UniProtKB Acc A9ANT2
UniProtKB ID A9ANT2_BURM1

Product

Feature Type CDS
Coding Frame 1
Product Name
BceA
Product Name Confidence: Class 2
Synonyms mannose-1-phosphate guanylyltransferase
Evidence for Translation
Charge (pH 7) -12.08
Kyte-Doolittle Hydrophobicity Value -0.132
Molecular Weight (kDa) 55245.0
Isoelectric Point (pI) 5.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 470 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003312 (1226 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bmul_4920
Search term: bceA
Search term: BceA

Human Homologs

References

Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863
The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities.
Sousa SA, Moreira LM, Wopperer J, Eberl L, Sá-Correia I, Leitão JH
Biochem Biophys Res Commun 2007 Feb 2;353(1):200-6
PubMed ID: 17184737
Functional analysis of the Burkholderia cenocepacia J2315 BceAJ protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities.
Sousa SA, Moreira LM, Leitão JH
Appl Microbiol Biotechnol 2008 Oct;80(6):1015-22
PubMed ID: 18668237