Burkholderia multivorans ATCC 17616, Bmul_4918 (bceC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1
GCF_000018505.1|latest
Locus Tag
Bmul_4918
NCBI Locus TagBMUL_RS24810
Name
bceC
Replicon chromosome 2
Genomic location 2041902 - 2043314 (- strand)
CommentMember of the bce-I gene cluster

Cross-References

RefSeq WP_006413973.1
GI 161521454
Entrez 5768553
GI 161521454
NCBI Locus Tag BMUL_RS24810
NCBI Old Locus Tag Bmul_4918
RefSeq WP_006413973.1
UniProtKB Acc A9ANT0
UniProtKB ID A9ANT0_BURM1

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-Glucose Dehydrogenase BceC
Product Name Confidence: Class 2
Synonyms nucleotide sugar dehydrogenase
Evidence for Translation
Charge (pH 7) -6.96
Kyte-Doolittle Hydrophobicity Value -0.175
Molecular Weight (kDa) 51177.4
Isoelectric Point (pI) 5.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2Y0E OXIDOREDUCTASE 12/02/10 BceC and the final step of UGDs reaction BURKHOLDERIA CEPACIA 1.75 X-RAY DIFFRACTION 94.0
2Y0D OXIDOREDUCTASE 12/02/10 BceC mutation Y10K BURKHOLDERIA CEPACIA 2.8 X-RAY DIFFRACTION 93.8
2Y0C OXIDOREDUCTASE 12/02/10 BceC mutation Y10S BURKHOLDERIA CEPACIA 1.75 X-RAY DIFFRACTION 93.8

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 588 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000893 (1284 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bmul_4918
Search term: bceC

Human Homologs

Ensembl 97, assembly GRCh38.p12
UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525]
E-value: 3.5e-64
Percent Identity: 35.4
Ensembl 97, assembly GRCh38.p12
UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525]
E-value: 3.5e-64
Percent Identity: 35.4

References

Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863
Structure of Burkholderia cepacia UDP-glucose dehydrogenase (UGD) BceC and role of Tyr10 in final hydrolysis of UGD thioester intermediate.
Rocha J, Popescu AO, Borges P, Mil-Homens D, Moreira LM, Sá-Correia I, Fialho AM, Frazão C
J Bacteriol 2011 Aug;193(15):3978-87
PubMed ID: 21602353
Cloning, expression, purification, crystallization and preliminary crystallographic studies of BceC, a UDP-glucose dehydrogenase from Burkholderia cepacia IST408.
Rocha J, Popescu AO, Sá-Correia I, Fialho AM, Frazão C
Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Mar 1;66(Pt 3):269-71
PubMed ID: 20208157