Burkholderia multivorans ATCC 17616, Bmul_4612 (bceN)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1
GCF_000018505.1|latest
Locus Tag
Bmul_4612
NCBI Locus TagBMUL_RS23330
Name
bceN
Replicon chromosome 2
Genomic location 1715959 - 1717002 (+ strand)
CommentMember of the bce-II gene cluster

Cross-References

RefSeq WP_012217290.1
GI 161521155
Entrez 5768382
GI 161521155
NCBI Locus Tag BMUL_RS23330
NCBI Old Locus Tag Bmul_4612
RefSeq WP_012217290.1
UniProtKB Acc A9AM97
UniProtKB ID A9AM97_BURM1

Product

Feature Type CDS
Coding Frame 1
Product Name
GDP-D-mannose 4,6-dehydratase BceN
Product Name Confidence: Class 2
Synonyms GDP-mannose 4,6-dehydratase
Evidence for Translation
Charge (pH 7) 0.60
Kyte-Doolittle Hydrophobicity Value -0.314
Molecular Weight (kDa) 38975.9
Isoelectric Point (pI) 7.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 609 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003102 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bmul_4612
Search term: bceN

Human Homologs

Ensembl 97, assembly GRCh38.p12
GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369]
E-value: 3.0e-97
Percent Identity: 53.6

References

Biochemical and functional studies on the Burkholderia cepacia complex bceN gene, encoding a GDP-D-mannose 4,6-dehydratase.
Sousa SA, Feliciano JR, Pinheiro PF, Leitão JH
PLoS One 2013;8(2):e56902
PubMed ID: 23460819
Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863