Burkholderia multivorans ATCC 17616, Bmul_3337 (hmuS)

Gene Feature Overview

Strain	Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1 GCF_000018505.1|latest
Locus Tag	Bmul_3337
NCBI Locus Tag	BMUL_RS16895
Name	hmuS
Replicon	chromosome 2
Genomic location	221796 - 222926 (- strand)
Comment	Member of the hemin uptake (hmu) operon

Cross-References

RefSeq	YP_001583313.1
GI	161519886
Entrez	5768157
GI	161519886
INSDC	ABX17021.1
NCBI Locus Tag	BMUL_RS16895
NCBI Old Locus Tag	Bmul_3337
RefSeq	YP_001583313.1
UniParc	UPI0000E9023B
UniProtKB Acc	A9ALR4
UniProtKB ID	A9ALR4_BURM1
UniRef100	UniRef100_A9ALR4
UniRef50	UniRef50_A3P229
UniRef90	UniRef90_A9ALR4

Product

Feature Type	CDS
Coding Frame	1
Product Name	cytoplasmic heme-binding protein/heme oxygenase HmuS
Synonyms	hemin-degrading family protein
Evidence for Translation
Charge (pH 7)	5.59
Kyte-Doolittle Hydrophobicity Value	-0.271
Molecular Weight (kDa)	41464.7
Isoelectric Point (pI)	9.01

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 96 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG004243 (594 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: Bmul_3337 Search term: hmuS Search term: cytoplasmic heme-binding protein/heme oxygenase HmuS

Human Homologs

References

The Small Protein HemP Is a Transcriptional Activator for the Hemin Uptake Operon in Burkholderia multivorans ATCC 17616. Sato T, Nonoyama S, Kimura A, Nagata Y, Ohtsubo Y, Tsuda M Appl Environ Microbiol 2017 Aug 15;83(16) PubMed ID: 28625994

Burkholderia pseudomallei known siderophores and hemin uptake are dispensable for lethal murine melioidosis. Kvitko BH, Goodyear A, Propst KL, Dow SW, Schweizer HP PLoS Negl Trop Dis 2012;6(6):e1715 PubMed ID: 22745846