Burkholderia multivorans ATCC 17616, Bmul_3335 (hmuU)

Gene Feature Overview

Strain	Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1 GCF_000018505.1|latest
Locus Tag	Bmul_3335
NCBI Locus Tag	BMUL_RS16885
Name	hmuU
Replicon	chromosome 2
Genomic location	219782 - 220873 (- strand)
Comment	Member of the hemin uptake (hmu) operon

Cross-References

RefSeq	WP_012216313.1
GI	161519884
Entrez	5768401
GI	161519884
NCBI Locus Tag	BMUL_RS16885
NCBI Old Locus Tag	Bmul_3335
RefSeq	WP_012216313.1
UniProtKB Acc	A9ALR2
UniProtKB ID	A9ALR2_BURM1

Product

Feature Type	CDS
Coding Frame	1
Product Name	permease subunit of inner membrane heme transporter HmuU
Synonyms	transport system permease
Evidence for Translation
Charge (pH 7)	14.52
Kyte-Doolittle Hydrophobicity Value	1.025
Molecular Weight (kDa)	35809.0
Isoelectric Point (pI)	11.70

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 552 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG004245 (593 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: Bmul_3335 Search term: hmuU Search term: permease subunit of inner membrane heme transporter HmuU

Human Homologs

References

The Small Protein HemP Is a Transcriptional Activator for the Hemin Uptake Operon in Burkholderia multivorans ATCC 17616. Sato T, Nonoyama S, Kimura A, Nagata Y, Ohtsubo Y, Tsuda M Appl Environ Microbiol 2017 Aug 15;83(16) PubMed ID: 28625994

Burkholderia pseudomallei known siderophores and hemin uptake are dispensable for lethal murine melioidosis. Kvitko BH, Goodyear A, Propst KL, Dow SW, Schweizer HP PLoS Negl Trop Dis 2012;6(6):e1715 PubMed ID: 22745846