Burkholderia multivorans ATCC 17616, Bmul_2558 (ldhA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1
GCF_000018505.1|latest
Locus Tag
Bmul_2558
NCBI Locus TagBMUL_RS12985
Name
ldhA
Replicon chromosome 1
Genomic location 2784693 - 2785691 (+ strand)

Cross-References

RefSeq WP_012214023.1
GI 161525727
Entrez 5767388
GI 161525727
NCBI Locus Tag BMUL_RS12985
NCBI Old Locus Tag Bmul_2558
RefSeq WP_012214023.1
UniProtKB Acc A9AFM1
UniProtKB ID A9AFM1_BURM1

Product

Feature Type CDS
Coding Frame 1
Product Name
D-Lactate Dehydrogenase LdhA
Product Name Confidence: Class 1
Synonyms D-isomer specific 2-hydroxyacid dehydrogenase
Evidence for Translation
Charge (pH 7) -5.21
Kyte-Doolittle Hydrophobicity Value 0.157
Molecular Weight (kDa) 36098.9
Isoelectric Point (pI) 6.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 640 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000687 (643 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bmul_2558
Search term: ldhA

Human Homologs

Ensembl 97, assembly GRCh38.p12
phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923]
E-value: 1.1e-30
Percent Identity: 34.5
Ensembl 97, assembly GRCh38.p12
phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923]
E-value: 1.1e-30
Percent Identity: 34.5
Ensembl 97, assembly GRCh38.p12
phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923]
E-value: 1.1e-30
Percent Identity: 34.5
Ensembl 97, assembly GRCh38.p12
phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923]
E-value: 1.1e-30
Percent Identity: 34.5
Ensembl 97, assembly GRCh38.p12
phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923]
E-value: 1.1e-30
Percent Identity: 34.5
Ensembl 97, assembly GRCh38.p12
phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923]
E-value: 1.1e-30
Percent Identity: 34.5

References

Regulator LdhR and d-Lactate Dehydrogenase LdhA of Burkholderia multivorans Play Roles in Carbon Overflow and in Planktonic Cellular Aggregate Formation.
Silva IN, Ramires MJ, Azevedo LA, Guerreiro AR, Tavares AC, Becker JD, Moreira LM
Appl Environ Microbiol 2017 Oct 1;83(19)
PubMed ID: 28733286