Burkholderia multivorans ATCC 17616, Bmul_2132 (hpnK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1
GCF_000018505.1|latest
Locus Tag
Bmul_2132
NCBI Locus TagBMUL_RS10780
Name
hpnK
Replicon chromosome 1
Genomic location 2345386 - 2346270 (- strand)
CommentBelongs to putative hopanoid biosynthesis gene cluster

Cross-References

RefSeq WP_012213765.1
GI 161525302
Entrez 5765320
GI 161525302
NCBI Locus Tag BMUL_RS10780
NCBI Old Locus Tag Bmul_2132
RefSeq WP_012213765.1
UniProtKB Acc A9AD30
UniProtKB ID A9AD30_BURM1

Product

Feature Type CDS
Coding Frame 1
Product Name
hopanoid biosynthesis associated protein HpnK
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.58
Kyte-Doolittle Hydrophobicity Value 0.069
Molecular Weight (kDa) 31202.4
Isoelectric Point (pI) 8.73

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 120 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001015 (648 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bmul_2132
Search term: hpnK

Human Homologs

References

Identification of hopanoid biosynthesis genes involved in polymyxin resistance in Burkholderia multivorans.
Malott RJ, Steen-Kinnaird BR, Lee TD, Speert DP
Antimicrob Agents Chemother 2012 Jan;56(1):464-71
PubMed ID: 22006009