Burkholderia dolosa AU0158, AK34_RS08380 (rpfR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia dolosa AU0158 (complete genome)
GCF_000959505.1|latest
Locus Tag
AK34_RS08380
NCBI Old Locus TagAK34_4835
Name
rpfR
Synonym: BDAG_04275
Replicon chromosome 2
Genomic location 1923734 - 1925737 (- strand)

Cross-References

RefSeq WP_035974932.1
GI 738013551
NCBI Locus Tag AK34_RS08380
NCBI Old Locus Tag AK34_4835
RefSeq WP_035974932.1

Product

Feature Type CDS
Coding Frame 1
Product Name
cis-2-dodecenoic acid receptor RpfR
Product Name Confidence: Class 2
Synonyms RNase II stability modulator
Evidence for Translation
Charge (pH 7) -11.54
Kyte-Doolittle Hydrophobicity Value -0.059
Molecular Weight (kDa) 73405.5
Isoelectric Point (pI) 5.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004646 (511 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: AK34_RS08380
Search term: rpfR

References

Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH
Proc Natl Acad Sci U S A 2012 Sep 18;109(38):15479-84
PubMed ID: 22949660
Mutation of the cyclic di-GMP phosphodiesterase gene in Burkholderia lata SK875 attenuates virulence and enhances biofilm formation.
Jung HI, Kim YJ, Lee YJ, Lee HS, Lee JK, Kim SK
J Microbiol 2017 Oct;55(10):800-808
PubMed ID: 28956352
High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.
Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, Tolker-Nielsen T, Jenal U, Eberl L
Microbiology 2017 May;163(5):754-764
PubMed ID: 28463102
Cis-2-dodecenoic acid quorum sensing system modulates N-acyl homoserine lactone production through RpfR and cyclic di-GMP turnover in Burkholderia cenocepacia.
Deng Y, Lim A, Wang J, Zhou T, Chen S, Lee J, Dong YH, Zhang LH
BMC Microbiol 2013 Jul 1;13:148
PubMed ID: 23815566