Burkholderia mallei NCTC 10247, BMA10247_A0752 (bicA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia mallei NCTC 10247
GCF_000015625.1|latest
Locus Tag
BMA10247_A0752
NCBI Locus TagBMA10247_RS03085
Name
bicA
Replicon chromosome II
Genomic location 695778 - 696293 (+ strand)

Cross-References

RefSeq WP_004188618.1
GI 126447932
Entrez 4890880
GI 126447932
INSDC ABO03898.1
NCBI Locus Tag BMA10247_RS03085
NCBI Old Locus Tag BMA10247_A0752
RefSeq WP_004188618.1
UniParc UPI000043BD1F
UniProtKB Acc A3MCG7
UniProtKB ID A3MCG7_BURM7
UniRef100 UniRef100_A0A069B9Y9
UniRef50 UniRef50_Q7NUS7
UniRef90 UniRef90_I1WUC1

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion chaperone BicA
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -7.93
Kyte-Doolittle Hydrophobicity Value -0.227
Molecular Weight (kDa) 19198.5
Isoelectric Point (pI) 4.71

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 28 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019836 (323 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BMA10247_A0752
Search term: bicA

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Type III secretion chaperone-dependent regulation: activation of virulence genes by SicA and InvF in Salmonella typhimurium.
Darwin KH, Miller VL
EMBO J 2001 Apr 17;20(8):1850-62
PubMed ID: 11296219