Burkholderia mallei NCTC 10247, BMA10247_A0732 (orgA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia mallei NCTC 10247
GCF_000015625.1|latest
Locus Tag
BMA10247_A0732
NCBI Locus TagBMA10247_RS02995
Name
orgA
Replicon chromosome II
Genomic location 678531 - 679133 (- strand)

Cross-References

RefSeq YP_001077933.1
GI 126447233
Entrez 4889610
GI 126447233
NCBI Locus Tag BMA10247_RS02995
NCBI Old Locus Tag BMA10247_A0732
RefSeq YP_001077933.1
UniProtKB Acc A3MCE7
UniProtKB ID A3MCE7_BURM7

Product

Feature Type CDS
Coding Frame 1
Product Name
Oxygen-regulated invasion protein OrgA
Product Name Confidence: Class 2
Synonyms type III secretion apparatus protein OrgA/MxiK
Evidence for Translation
Charge (pH 7) 4.03
Kyte-Doolittle Hydrophobicity Value 0.071
Molecular Weight (kDa) 21662.7
Isoelectric Point (pI) 8.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 9 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019862 (315 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BMA10247_A0732
Search term: orgA

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592