Burkholderia mallei NCTC 10247, BMA10247_A0731 (orgB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia mallei NCTC 10247
GCF_000015625.1|latest
Locus Tag
BMA10247_A0731
NCBI Locus TagBMA10247_RS02990
Name
orgB
Replicon chromosome II
Genomic location 677768 - 678562 (- strand)

Cross-References

RefSeq WP_004188436.1
GI 126446460
Entrez 4890541
GI 126446460
INSDC ABO02426.1
NCBI Locus Tag BMA10247_RS02990
NCBI Old Locus Tag BMA10247_A0731
RefSeq WP_004188436.1
UniParc UPI0000441489
UniProtKB Acc A3MCE6
UniProtKB ID A3MCE6_BURM7
UniRef100 UniRef100_A0A097XJT2
UniRef50 UniRef50_Q2T731
UniRef90 UniRef90_A3NLF7

Product

Feature Type CDS
Coding Frame 1
Product Name
Oxygen-regulated invasion protein OrgB
Product Name Confidence: Class 2
Synonyms HrpE/YscL family type III secretion apparatus protein
Evidence for Translation
Charge (pH 7) -1.67
Kyte-Doolittle Hydrophobicity Value -0.296
Molecular Weight (kDa) 28197.1
Isoelectric Point (pI) 6.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 4 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG017454 (359 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BMA10247_A0731
Search term: orgB

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592