Burkholderia cenocepacia MC0-3, Bcenmc03_5574 (cepI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia MC0-3
GCF_000019505.1|latest
Locus Tag
Bcenmc03_5574
NCBI Locus TagBCENMC03_RS27900
Name
cepI
Replicon chromosome 2
Genomic location 2717667 - 2718275 (- strand)

Cross-References

RefSeq WP_012339764.1
GI 170737929
Entrez 6128382
GI 170737929
INSDC ACA94699.1
NCBI Locus Tag BCENMC03_RS27900
NCBI Old Locus Tag Bcenmc03_5574
RefSeq WP_012339764.1
UniParc UPI0000E9A480
UniProtKB Acc B1K9T4
UniProtKB ID B1K9T4_BURCC
UniRef100 UniRef100_B1K9T4
UniRef50 UniRef50_O30920
UniRef90 UniRef90_B4EMD2

Product

Feature Type CDS
Coding Frame 1
Product Name
autoinducer synthesis protein
Product Name Confidence: Class 1
Synonyms acyl-homoserine lactone synthase CepI
autoinducer synthase CepI
Evidence for Translation
Charge (pH 7) -5.16
Kyte-Doolittle Hydrophobicity Value -0.137
Molecular Weight (kDa) 22323.2
Isoelectric Point (pI) 5.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0433
Category Quorum sensing system
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 63 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003720 (981 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bcenmc03_5574
Search term: cepI

Human Homologs

References

Distribution of quorum-sensing genes in the Burkholderia cepacia complex.
Lutter E, Lewenza S, Dennis JJ, Visser MB, Sokol PA
Infect Immun 2001 Jul;69(7):4661-6
PubMed ID: 11402012