Burkholderia cenocepacia MC0-3, Bcenmc03_6493 (afcA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia MC0-3
GCF_000019505.1|latest
Locus Tag
Bcenmc03_6493
NCBI Locus TagBCENMC03_RS32465
Name
afcA
Replicon chromosome 3
Genomic location 548991 - 550793 (+ strand)

Cross-References

RefSeq WP_012337002.1
GI 170734989
Entrez 6125416
GI 170734989
INSDC ACA95608.1
NCBI Locus Tag BCENMC03_RS32465
NCBI Old Locus Tag Bcenmc03_6493
RefSeq WP_012337002.1
UniParc UPI0000E91FCE
UniProtKB Acc B1KBL1
UniProtKB ID B1KBL1_BURCC
UniRef100 UniRef100_B1KBL1
UniRef50 UniRef50_W8ZJN4
UniRef90 UniRef90_W8ZJN4

Product

Feature Type CDS
Coding Frame 1
Product Name
AMP-dependent synthetase and ligase
Product Name Confidence: Class 1
Synonyms putative amino acid activating protein
Evidence for Translation
Charge (pH 7) -3.20
Kyte-Doolittle Hydrophobicity Value 0.076
Molecular Weight (kDa) 63896.1
Isoelectric Point (pI) 6.65

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 571 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001460 (2297 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bcenmc03_6493
Search term: afcA

Human Homologs

Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526]
E-value: 5.1e-07
Percent Identity: 44.3
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526]
E-value: 5.1e-07
Percent Identity: 44.3
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526]
E-value: 5.1e-07
Percent Identity: 44.3
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526]
E-value: 5.1e-07
Percent Identity: 44.3
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526]
E-value: 5.1e-07
Percent Identity: 44.3

References

Characterization of genes involved in biosynthesis of a novel antibiotic from Burkholderia cepacia BC11 and their role in biological control of Rhizoctonia solani.
Kang Y, Carlson R, Tharpe W, Schell MA
Appl Environ Microbiol 1998 Oct;64(10):3939-47
PubMed ID: 9758823