Strain |
Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest |
Locus Tag |
BTH_I2962
|
NCBI Locus Tag | BTH_RS27300 |
Name |
hcp-1
|
Replicon | chromosome I |
Genomic location | 3409765 - 3410268 (- strand) |
Transposon Mutants | 2 transposon mutants in E264 ATCC 700388 |
Comment | This gene is part of cluster known as the type VI secretion system gene cluster tss-1 based on naming convention used for B. pseudomallei described in PMID:17660433, however unlike B. pseudomallei, the numbers following the vgrG and hcp gene match the cluster number (PMID:20865170). |
RefSeq | YP_443469.1 |
GI | 83721066 |
Entrez | 3848445 |
GI | 83721066 |
INSDC | AIP27769.1 |
NCBI Locus Tag | BTH_RS27300 |
NCBI Old Locus Tag | BTH_I2962 |
RefSeq | WP_009906860.1 |
UniParc | UPI000066853E |
UniProtKB Acc | Q2SUD0 |
UniProtKB ID | Q2SUD0_BURTA |
UniRef100 | UniRef100_Q2SUD0 |
UniRef50 | UniRef50_D8N062 |
UniRef90 | UniRef90_I1WF16 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
type VI secretion system protein TssD-1
|
Synonyms |
hypothetical protein hcp-1 |
Evidence for Translation | |
Charge (pH 7) | -0.12 |
Kyte-Doolittle Hydrophobicity Value | -0.493 |
Molecular Weight (kDa) | 18347.5 |
Isoelectric Point (pI) | 6.97 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 81 genera
|
Burkholderia Ortholog Group |
BG000368 (644 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BTH_I2962
Search term: hcp-1
Search term: type VI secretion system protein TssD-1
|
Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.
Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD
PLoS Pathog 2010 Aug 26;6(8):e1001068
PubMed ID: 20865170
|
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
|
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
|
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434
|