Burkholderia thailandensis E264 ATCC 700388, BTH_I2391 (mftR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_I2391
NCBI Locus TagBTH_RS24400
Name
mftR
Replicon chromosome I
Genomic location 2719001 - 2719495 (- strand)
Transposon Mutants 2 transposon mutants in E264 ATCC 700388

Cross-References

RefSeq YP_442912.1
GI 83720383
Entrez 3847515
GI 83720383
INSDC AIP25924.1
NCBI Locus Tag BTH_RS24400
NCBI Old Locus Tag BTH_I2391
RefSeq WP_009891131.1
UniParc UPI00006682B5
UniProtKB Acc Q2SVY7
UniProtKB ID Q2SVY7_BURTA
UniRef100 UniRef100_Q2SVY7
UniRef50 UniRef50_I3TII8
UniRef90 UniRef90_Q2SVY7

Product

Feature Type CDS
Coding Frame 1
Product Name
major facilitator transport regulator MftR
Product Name Confidence: Class 1
Synonyms MarR family transcriptional regulator
Evidence for Translation
Charge (pH 7) 1.47
Kyte-Doolittle Hydrophobicity Value -0.212
Molecular Weight (kDa) 17815.0
Isoelectric Point (pI) 9.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 301 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001499 (736 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_I2391
Search term: mftR

Human Homologs

References

Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.
Gupta A, Bedre R, Thapa SS, Sabrin A, Wang G, Dassanayake M, Grove A
ACS Chem Biol 2017 Dec 15;12(12):3012-3021
PubMed ID: 29087175
Ligand-binding pocket bridges DNA-binding and dimerization domains of the urate-responsive MarR homologue MftR from Burkholderia thailandensis.
Gupta A, Grove A
Biochemistry 2014 Jul 15;53(27):4368-80
PubMed ID: 24955985
Urate-responsive MarR homologs from Burkholderia.
Grove A
Mol Biosyst 2010 Nov;6(11):2133-42
PubMed ID: 20730247