Burkholderia thailandensis E264 ATCC 700388, BTH_I1476 (wbiB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_I1476
NCBI Locus TagBTH_RS19730
Name
wbiB
Replicon chromosome I
Genomic location 1671594 - 1672685 (+ strand)
Transposon Mutants 2 transposon mutants in E264 ATCC 700388

Cross-References

RefSeq YP_442022.1
GI 83719479
Entrez 3849621
GI 83719479
NCBI Locus Tag BTH_RS19730
NCBI Old Locus Tag BTH_I1476
RefSeq WP_009889595.1
UniProtKB Acc Q2SYH7
UniProtKB ID Q2SYH7_BURTA

Product

Feature Type CDS
Coding Frame 1
Product Name
dTDP-Rha 4-epimerase
Product Name Confidence: Class 1
Synonyms UDP-glucose 4-epimerase
Evidence for Translation
Charge (pH 7) -5.65
Kyte-Doolittle Hydrophobicity Value -0.069
Molecular Weight (kDa) 39159.0
Isoelectric Point (pI) 6.00

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 635 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020051 (308 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_I1476
Search term: wbiB

Human Homologs

Ensembl 97, assembly GRCh38.p12
UDP-glucuronate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:17729]
E-value: 2.6e-14
Percent Identity: 22.4
Ensembl 97, assembly GRCh38.p12
UDP-glucuronate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:17729]
E-value: 2.6e-14
Percent Identity: 22.4

References

A new route to dTDP-6-deoxy-l-talose and dTDP-L-rhamnose: dTDP-L-rhamnose 4-epimerase in Burkholderia thailandensis.
Yoo HG, Kwon SY, Karki S, Kwon HJ
Bioorg Med Chem Lett 2011 Jul 1;21(13):3914-7
PubMed ID: 21640586