Burkholderia thailandensis E264 ATCC 700388, BTH_II2097 (malK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II2097
NCBI Locus TagBTH_RS10730
Name
malK
Replicon chromosome II
Genomic location 2576437 - 2576868 (+ strand)
CommentBelongs to the malleilactone biosynthetic gene cluster

Cross-References

RefSeq YP_440285.1
GI 83716966
Entrez 3846260
GI 83716966
INSDC AIP25004.1
NCBI Locus Tag BTH_RS10730
NCBI Old Locus Tag BTH_II2097
RefSeq WP_009894057.1
UniParc UPI00006675E6
UniProtKB Acc Q2T3G4
UniProtKB ID Q2T3G4_BURTA
UniRef100 UniRef100_Q2T3G4
UniRef50 UniRef50_Q2T3G4
UniRef90 UniRef90_Q2T3G4

Product

Feature Type CDS
Coding Frame 1
Product Name
MalK
Synonyms putative lipoprotein
Evidence for Translation
Charge (pH 7) 6.12
Kyte-Doolittle Hydrophobicity Value 0.737
Molecular Weight (kDa) 15843.7
Isoelectric Point (pI) 9.90

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Pathogenic
Found only in pathogenic strains
Hits to this gene were found in one genus

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019790 (368 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II2097
Search term: malK
Search term: MalK

Human Homologs

References

Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.
Gupta A, Bedre R, Thapa SS, Sabrin A, Wang G, Dassanayake M, Grove A
ACS Chem Biol 2017 Dec 15;12(12):3012-3021
PubMed ID: 29087175
Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.
Biggins JB, Ternei MA, Brady SF
J Am Chem Soc 2012 Aug 15;134(32):13192-5
PubMed ID: 22765305