Burkholderia thailandensis E264 ATCC 700388, BTH_II2090 (malC)

Gene Feature Overview

Strain	Burkholderia thailandensis E264 ATCC 700388 GCF_000012365.1|latest
Locus Tag	BTH_II2090
NCBI Locus Tag	BTH_RS10690
Name	malC
Replicon	chromosome II
Genomic location	2554346 - 2555740 (+ strand)
Transposon Mutants	2 transposon mutants in E264 ATCC 700388
Comment	Belongs to the malleilactone biosynthetic gene cluster

Cross-References

RefSeq	YP_440278.1
GI	83717350
Entrez	3846721
GI	83717350
INSDC	ABC35239.1
NCBI Locus Tag	BTH_RS10690
NCBI Old Locus Tag	BTH_II2090
RefSeq	YP_440278.1
UniParc	UPI000066775D
UniProtKB Acc	Q2T3H1
UniProtKB ID	Q2T3H1_BURTA
UniRef100	UniRef100_Q2T3H1
UniRef50	UniRef50_Q2T3H1
UniRef90	UniRef90_Q2T3H1

Product

Feature Type	CDS
Coding Frame	1
Product Name	MalC
Synonyms	syringomycin synthesis regulator SyrP
Evidence for Translation
Charge (pH 7)	24.49
Kyte-Doolittle Hydrophobicity Value	-0.622
Molecular Weight (kDa)	52141.3
Isoelectric Point (pI)	10.69

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 71 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG019779 (374 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BTH_II2090 Search term: malC Search term: MalC

Human Homologs

References

Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis. Gupta A, Bedre R, Thapa SS, Sabrin A, Wang G, Dassanayake M, Grove A ACS Chem Biol 2017 Dec 15;12(12):3012-3021 PubMed ID: 29087175

Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens. Biggins JB, Ternei MA, Brady SF J Am Chem Soc 2012 Aug 15;134(32):13192-5 PubMed ID: 22765305