Burkholderia thailandensis E264 ATCC 700388, BTH_II2087 (malR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II2087
Name
malR
Synonym: btaR4
Replicon chromosome II
Genomic location 2543245 - 2544522 (- strand)
Transposon Mutants 2 transposon mutants in E264 ATCC 700388
CommentBelongs to the malleilactone biosynthetic gene cluster

Cross-References

RefSeq YP_440275.1
GI 83716463
Entrez 3845671
GI 83716463
INSDC ABC34352.1
NCBI Locus Tag BTH_II2087
RefSeq YP_440275.1
UniParc UPI00006673FF
UniProtKB Acc Q2T3H4
UniProtKB ID Q2T3H4_BURTA
UniRef100 UniRef100_Q2T3H4
UniRef50 UniRef50_Q3JHD3
UniRef90 UniRef90_Q2T3H4

Product

Feature Type CDS
Coding Frame 1
Product Name
MalR
Product Name Confidence: Class 1
Synonyms ATP-dependent transcription regulator LuxR
Evidence for Translation
Charge (pH 7) 44.21
Kyte-Doolittle Hydrophobicity Value -0.308
Molecular Weight (kDa) 47074.4
Isoelectric Point (pI) 11.84

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0433
Category Quorum sensing system
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 221 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019771 (338 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II2087
Search term: malR
Search term: MalR

Human Homologs

References

Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.
Gupta A, Bedre R, Thapa SS, Sabrin A, Wang G, Dassanayake M, Grove A
ACS Chem Biol 2017 Dec 15;12(12):3012-3021
PubMed ID: 29087175
Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.
Biggins JB, Ternei MA, Brady SF
J Am Chem Soc 2012 Aug 15;134(32):13192-5
PubMed ID: 22765305