Burkholderia thailandensis E264 ATCC 700388, BTH_II1930 (hmqF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II1930
NCBI Locus TagBTH_RS09875
Name
hmqF
Replicon chromosome II
Genomic location 2346124 - 2350095 (- strand)
Transposon Mutants 4 transposon mutants in E264 ATCC 700388
CommentBelongs to the HMAQ biosynthesis operon hmqABCDEFG

Cross-References

RefSeq YP_440124.1
GI 83717455
Entrez 3846495
GI 83717455
INSDC ABC35344.1
NCBI Locus Tag BTH_RS09875
NCBI Old Locus Tag BTH_II1930
RefSeq YP_440124.1
UniParc UPI00006677C2
UniProtKB Acc Q2T3X5
UniProtKB ID Q2T3X5_BURTA
UniRef100 UniRef100_Q2T3X5
UniRef50 UniRef50_A0A095RDG3
UniRef90 UniRef90_A0A095RDG3

Product

Feature Type CDS
Coding Frame 1
Product Name
AMP-binding domain-containing protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -11.20
Kyte-Doolittle Hydrophobicity Value -0.087
Molecular Weight (kDa) 141855.5
Isoelectric Point (pI) 6.27

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 583 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG017410 (460 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II1930
Search term: hmqF

Human Homologs

Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase family member 3 [Source:HGNC Symbol;Acc:HGNC:27288]
E-value: 4.7e-13
Percent Identity: 21.8
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase family member 3 [Source:HGNC Symbol;Acc:HGNC:27288]
E-value: 4.7e-13
Percent Identity: 21.8
Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase family member 3 [Source:HGNC Symbol;Acc:HGNC:27288]
E-value: 4.7e-13
Percent Identity: 21.8

References

Burkholderia pseudomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation.
Vial L, Lépine F, Milot S, Groleau MC, Dekimpe V, Woods DE, Déziel E
J Bacteriol 2008 Aug;190(15):5339-52
PubMed ID: 18539738
Interplay between 4-Hydroxy-3-Methyl-2-Alkylquinoline and <i>N</i>-Acyl-Homoserine Lactone Signaling in a <i>Burkholderia cepacia</i> Complex Clinical Strain.
Chapalain A, Groleau MC, Le Guillouzer S, Miomandre A, Vial L, Milot S, Déziel E
Front Microbiol 2017;8:1021
PubMed ID: 28676791
Characterization of HmqF, a protein involved in the biosynthesis of unsaturated quinolones produced by Burkholderia thailandensis.
Agarwal A, Kahyaoglu C, Hansen DB
Biochemistry 2012 Feb 28;51(8):1648-57
PubMed ID: 22320268