Burkholderia thailandensis E264 ATCC 700388, BTH_II1899 (hcp-4)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II1899
NCBI Locus TagBTH_RS09720
Name
hcp-4
Replicon chromosome II
Genomic location 2304861 - 2305388 (- strand)
Transposon Mutants 3 transposon mutants in E264 ATCC 700388
CommentThis gene is part of cluster known as the type VI secretion system gene cluster tss-4 based on naming convention used for B. pseudomallei described in PMID:17660433, however unlike B. pseudomallei, the numbers following the vgrG and hcp gene match the cluster number (PMID:20865170).

Cross-References

RefSeq YP_440093.1
GI 83718015
Entrez 3846375
GI 83718015
INSDC AIP28747.1
NCBI Locus Tag BTH_RS09720
NCBI Old Locus Tag BTH_II1899
RefSeq WP_009901013.1
UniParc UPI00006679E4
UniProtKB Acc Q2T406
UniProtKB ID Q2T406_BURTA
UniRef100 UniRef100_Q2T406
UniRef50 UniRef50_A1UWJ9
UniRef90 UniRef90_A1UWJ9

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssD-4
Product Name Confidence: Class 2
Synonyms Hcp-4
hypothetical protein
Evidence for Translation
Charge (pH 7) -3.59
Kyte-Doolittle Hydrophobicity Value -0.315
Molecular Weight (kDa) 19206.6
Isoelectric Point (pI) 4.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 58 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019180 (327 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II1899
Search term: hcp-4

Human Homologs

References

Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.
Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD
PLoS Pathog 2010 Aug 26;6(8):e1001068
PubMed ID: 20865170
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434