Burkholderia thailandensis E264 ATCC 700388, BTH_II1893 (vgrG-4b)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II1893
NCBI Locus TagBTH_RS09690
Name
vgrG-4b
Replicon chromosome II
Genomic location 2293904 - 2296192 (- strand)
Transposon Mutants 2 transposon mutants in E264 ATCC 700388
CommentThis gene is part of cluster known as the type VI secretion system gene cluster tss-4 based on naming convention used for B. pseudomallei described in PMID:17660433, however unlike B. pseudomallei, the numbers following the vgrG and hcp gene match the cluster number (PMID:20865170).

Cross-References

RefSeq YP_440087.1
GI 83716389
Entrez 3844973
GI 83716389
INSDC AIP29238.1
NCBI Locus Tag BTH_RS09690
NCBI Old Locus Tag BTH_II1893
RefSeq WP_009893768.1
UniParc UPI00006673B7
UniProtKB Acc Q2T412
UniProtKB ID Q2T412_BURTA
UniRef100 UniRef100_Q2T412
UniRef50 UniRef50_I1WRE9
UniRef90 UniRef90_I1WRE9

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssI-4b
Product Name Confidence: Class 2
Synonyms Rhs element Vgr protein
VgrG-4b
Evidence for Translation
Charge (pH 7) -15.66
Kyte-Doolittle Hydrophobicity Value -0.297
Molecular Weight (kDa) 82413.7
Isoelectric Point (pI) 5.13

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 153 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019186 (318 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II1893
Search term: vgrG-4b

Human Homologs

References

Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.
Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD
PLoS Pathog 2010 Aug 26;6(8):e1001068
PubMed ID: 20865170
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434