Burkholderia thailandensis E264 ATCC 700388, BTH_II1237 (btaO)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II1237
NCBI Locus TagBTH_RS06335
Name
btaO
Replicon chromosome II
Genomic location 1474257 - 1476596 (+ strand)
Transposon Mutants 3 transposon mutants in E264 ATCC 700388
CommentBelongs to the bactobolin biosynthetic gene cluster

Cross-References

RefSeq YP_439433.1
GI 83716265
Entrez 3845988
GI 83716265
NCBI Locus Tag BTH_RS06335
NCBI Old Locus Tag BTH_II1237
RefSeq YP_439433.1
UniProtKB Acc Q2T5W6
UniProtKB ID Q2T5W6_BURTA

Product

Feature Type CDS
Coding Frame 1
Product Name
BtaO
Synonyms thiotemplate mechanism natural product synthetase
Evidence for Translation
Charge (pH 7) -9.72
Kyte-Doolittle Hydrophobicity Value -0.003
Molecular Weight (kDa) 81905.3
Isoelectric Point (pI) 6.12

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 571 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG021535 (270 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II1237
Search term: btaO
Search term: BtaO

Human Homologs

Ensembl 97, assembly GRCh38.p12
fatty acid synthase [Source:HGNC Symbol;Acc:HGNC:3594]
E-value: 8.2e-50
Percent Identity: 30.3
Ensembl 97, assembly GRCh38.p12
fatty acid synthase [Source:HGNC Symbol;Acc:HGNC:3594]
E-value: 8.2e-50
Percent Identity: 30.3

References

Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis.
Duerkop BA, Varga J, Chandler JR, Peterson SB, Herman JP, Churchill ME, Parsek MR, Nierman WC, Greenberg EP
J Bacteriol 2009 Jun;191(12):3909-18
PubMed ID: 19376863
Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264.
Carr G, Seyedsayamdost MR, Chandler JR, Greenberg EP, Clardy J
Org Lett 2011 Jun 17;13(12):3048-51
PubMed ID: 21615115
Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.
Seyedsayamdost MR, Chandler JR, Blodgett JA, Lima PS, Duerkop BA, Oinuma K, Greenberg EP, Clardy J
Org Lett 2010 Feb 19;12(4):716-9
PubMed ID: 20095633