Burkholderia thailandensis E264 ATCC 700388, BTH_II1227 (btaI2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II1227
NCBI Locus TagBTH_RS06285
Name
btaI2
Replicon chromosome II
Genomic location 1450117 - 1450737 (- strand)
Transposon Mutants 2 transposon mutants in E264 ATCC 700388
CommentBelongs to the bactobolin biosynthetic gene cluster

Cross-References

RefSeq YP_439423.1
GI 83716178
Entrez 3845892
GI 83716178
NCBI Locus Tag BTH_RS06285
NCBI Old Locus Tag BTH_II1227
RefSeq WP_009896821.1
UniProtKB Acc Q2T5X6
UniProtKB ID Q2T5X6_BURTA

Product

Feature Type CDS
Coding Frame 1
Product Name
acyl-homoserine lactone synthase BtaI2
Product Name Confidence: Class 1
Synonyms N-acyl homoserine lactone synthase
Evidence for Translation
Charge (pH 7) -0.96
Kyte-Doolittle Hydrophobicity Value 0.155
Molecular Weight (kDa) 22265.5
Isoelectric Point (pI) 6.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0433
Category Quorum sensing system
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 63 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG017595 (364 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II1227
Search term: btaI2

Human Homologs

References

Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis.
Duerkop BA, Varga J, Chandler JR, Peterson SB, Herman JP, Churchill ME, Parsek MR, Nierman WC, Greenberg EP
J Bacteriol 2009 Jun;191(12):3909-18
PubMed ID: 19376863
Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264.
Carr G, Seyedsayamdost MR, Chandler JR, Greenberg EP, Clardy J
Org Lett 2011 Jun 17;13(12):3048-51
PubMed ID: 21615115
Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.
Seyedsayamdost MR, Chandler JR, Blodgett JA, Lima PS, Duerkop BA, Oinuma K, Greenberg EP, Clardy J
Org Lett 2010 Feb 19;12(4):716-9
PubMed ID: 20095633
The Complex Quorum Sensing Circuitry of <i>Burkholderia thailandensis</i> Is Both Hierarchically and Homeostatically Organized.
Le Guillouzer S, Groleau MC, Déziel E
mBio 2017 Dec 5;8(6)
PubMed ID: 29208745